Ding ding ding, the fucking pope is dead. It became this thing where I was going to try to get hired and I was in the building and I applied for every job and tried to freelance for every editor and I was the ubiquitous guy. He was the editor of the metro section. I just kind of decided I was going to do that. I just love it. I love typing.
I need something to type about. I love it.
You could spend a whole day going from desk to desk, talking to people, and one was smarter and brighter than the next. But they were Washington people who lacked some of the dimension I wanted for my work, that I had to leave to go do. But I learned the bedrock of what I do by doing it their way, which was fucking impeccable shit.
I mean, Bob Woodward was your boss. Harrington gave me The New Journalism. The process is like shoveling a huge pile of shit and then you have to go climb up it. What I do is not the most popular thing. The perfect length today is the like to thousand-word [story]. Yeah, and like Rolling Stone sometimes, and Esquire has really published my longest stuff.
I need a good strong editor, because most editors know what they want. How does that work for you with the Sager Group, since you are effectively the editor? Peter Griffin, my editor at Esquire , is great at making tweaks in my brain along the way. But I work it until it is done. Chronic users who start in their adolescence, for example, before their cognitive functions have matured, may develop long-term handicaps, including reduced verbal fluency. The effects of cannabis on anxiety and depression are not fully understood.
More research, taking environmental and genetic factors into account, is called for. The same is true of schizophrenia. Although a definite correlation exists between chronic cannabis use and psychosis, the relationship might not be causal.
Pregnant and breastfeeding women should probably avoid cannabis. Although research is limited and often contradictory, there is evidence linking cannabis to ectopic pregnancies, miscarriages, attention deficit disorders, and slightly below-average birth weights. One final issue to mention, particularly affecting long-term cannabis users, is cannabinoid hyperemesis syndrome. This is a rare condition characterized by uncontrollable nausea, vomiting, and abdominal cramps, as well as a compulsion to take hot baths for relief. It can usually be treated with abstinence. The threshold dose for high potency cannabis, smoked, is 0.
A common dose is between 0. For medium potency cannabis, the common dose is 0. The effects from smoking are typically felt within the first 10 minutes—usually within the first minute—peaking at minutes before sloping off over the next hours.
For oral consumption, the dosage is measured by THC content. More experienced users often take up to 20 mg or more at a time. With the exception of sublingual tinctures, which have a similarly rapid onset to smoking,  the effects from orally consumed cannabis are felt within minutes, peaking at two to three hours and lasting for up to eight. Common effects include mood enhancement and euphoria, accompanied by laughter and relaxation, as well as an increased enjoyment of music, food, tactile sensations, and activities you normally find dull.
Thoughts tend to be more free flowing, often leading to creative and philosophical or spiritual insights. At higher doses, the flow of ideas can even become overwhelming. Panic attacks, confusion, memory loss, and depersonalization or derealization are some of the more negative effects of cannabis, along with the suppression of dreams. Otherwise, visual effects tend to be limited to color enhancement, moderate closed-eye patterns, and increased sensitivity to light.
Lethargic, slow movements are especially common on cannabis, even with the elevated heart rate. There are subtle differences between weed and hash as well, with the latter tending to give a clearer, more cerebral high. With edibles, there may be some anxiety and paranoia at first before giving way to a psychedelic body high and deep sleep. Driving on cannabis, and especially on edibles and extracts, is strongly discouraged. While many find it makes them drive slower, it also slows down reactions, posing a danger on the road. Higher potency cannabis should be avoided in public anyway, at least the first time, as the effects can be overwhelming.
The presence of different strains and unevenly distributed THC in edibles can also make them hard to predict. This involves starting with a L ow dose, E stablishing potency, going S low being patient for the onset of effects , and S upplementing as needed with more.
New cannabis smokers are often told to hold smoke in their lungs for as long as they can to fully absorb the cannabinoids. This is because early researchers measured THC by gas chromatography, which involved heating and therefore breaking down the molecule. The sample size is also much, much larger than it used to be.
In the s, researchers were lucky if they had access to 18 seizures in a year, whereas nowadays they have access to thousands. Evidence suggests that people only smoke as much as they need to reach their desired state. In other words, the higher the potency, the less users need—and ultimately, the fewer carcinogens they inhale. This Reefer Madness -style argument for continued prohibition has zero basis in fact. While it is true that most habitual drug users are exposed to cannabis before any harder drugs, this is only to be expected considering that cannabis is the most prevalent illicit substance worldwide.
But if it did, alcohol and tobacco would be the original gateway drugs, since most cocaine and heroin addicts are exposed to them even earlier. Withdrawal symptoms include irritability, lethargy, physical discomfort, difficulty sleeping, diminished appetite, and a loss of pleasure in once enjoyable activities anhedonia. Unlike withdrawal symptoms from other drugs, such as alcohol, tobacco, and heroin, these effects tend to be mild. They also tend to fade after two to four days, or within six weeks for heavy users.
The medical applications of cannabis are many and well known, and the list is continually growing. Substantial evidence, drawn from years of clinical research, supports its use as a treatment for nausea and vomiting in chemotherapy patients; appetite loss and wasting syndrome cachexia in HIV and cancer patients; spasticity in multiple sclerosis MS patients; and neuropathic or chronic pain, such as fibromyalgia. In addition to the clinical evidence, numerous anecdotal reports link total remission to the regular use of cannabis oil.
Rick Simpson, for example, claims to have cured his skin cancer by applying high-THC cannabis oil directly to the affected area. Cannabis and synthetic cannabinoid-based medications may also be used to treat cancer-related symptoms. For instance, Marinol works to stimulate appetite and reduce nausea and vomiting in chemotherapy patients, even when other antiemetics have failed. Studies have also found cannabis to be an effective analgesic, and one far safer than opioids. This is promising not only for cancer patients, but for sufferers of rheumatoid or osteoarthritis, as well as chronic pain in general.
Cannabis may also play an important role in stabilizing mood more generally. Not only do cannabinoids have an anti-depressant effect on serotonin release,  but chronic stress appears to downregulate endocannabinoid production. THC in particular may help treat depression by reducing negative bias in emotional processing.
A number of other studies, however, have associated cannabis with a higher incidence of depression or a deadening of emotion in general. Crucially for recovering addicts, it can also treat underlying issues like anxiety, depression, and trauma. According to one, it took just seven weeks for cannabis oil to improve the memory, mood, and physical mobility of a formerly catatonic patient.
When she was returned to a state-run facility and standard pharmaceutical treatment program, her condition again deteriorated. As an anti-inflammatory, for example, THC reduces inflammation in the brain and ultimately minimizes damage. CBD has proven to be an effective treatment for epilepsy, including rare forms such as Lennox-Gastaut and Dravet syndromes—both of which afflict young children with frequent, devastating seizures. Among migraine sufferers, daily cannabis inhalation is shown to reduce the frequency of headaches from just over 10 migraines per month to fewer than five for Cannabinoids have also been found to significantly reduce the intraocular pressure, pupil restriction, and conjunctival hyperemia associated with glaucoma.
Unfortunately, the high doses required may not be suitable for elderly patients, due to the cardiovascular and psychoactive effects. Some other promising indications for cannabis include osteoporosis, diabetes, inflammatory skin diseases like eczema , allergic reactions, and organ transplant rejection. This suggests that microdosing cannabis in later life could be a good defence against memory loss.
Many people report enhanced creativity from cannabis—an effect that is supported by science. The psychospiritual benefits of cannabis include deeper meditation and a sense of oneness or unity with people, the planet, and the universe. For an up-to-date list, see here. Unfortunately, decriminalization does nothing to undermine the criminal supply chain.
In the Netherlands, where cannabis has long been decriminalized for sale in coffee shops, the coffee shops themselves are forced to rely on the unregulated black market to source their product. This raises ethical and economic concerns, as well as health issues, since many unregulated growers are thought to make heavy use of inorganic pesticides. In the UK, against the recommendations of scientific advisors, medical professionals, politicians, and even police commissioners,   cannabis remains a Class B drug.
Possession is punishable by up to five years in prison, an unlimited fine, or both. While MS patients and only MS patients are allowed to use Sativex, the drug is prohibitively expensive everywhere but Wales. In Canada, where cannabis is a Schedule II drug, possession has been punishable by up to six months in jail and a CAD fine for the first offense, and up to one year in jail and a CAD fine for subsequent offenses. In addition to being able to buy cannabis from licensed producers or indeed sell it as one , Canadian adults will also be allowed to grow their own cannabis at home, as long as they have no more than 30 seeds in their possession and no more than four cannabis plants per residence.
High Tolerance: A Novel of Sex, Race, Celebrity, Murder and Marijuana eBook: Mike Sager: rapyzure.tk: Kindle Store. The wry and knowing Mike Sager has written a saucy and kinetic L.A. novel. High Tolerance: A Novel of Sex, Race, Celebrity, Murder and Marijuana.
The use of organic solvents to make concentrated cannabis products e. In Australia, cannabis is legal for medical use and scientific research. Cannabis has also been decriminalized or partially decriminalized in a number of European countries, including Austria, Germany, Italy, and Portugal.
Cannabis stays in the blood and urine for days. In formerly chronic, daily users, it may be possible to detect cannabis for up to 90 days, but isolated occasional use tends to clear the system in less than 10—and sometimes as little as two. Some strains of cannabis, and especially edibles and extracts, can be overwhelmingly strong for beginners. This usually depends on set and setting. The impact of cannabis on forming long-term memories is more nuanced, appearing only to affect the spatial episodic memory.
This means you may be liable to forget locations and layouts more easily than you forget events. Although a lethal overdose is practically unheard of, cannabis does carry a number of potential risks. These include psychological dependence, legal repercussions, and, as with exercise, cardiovascular abnormalities.
Try to relax yourself with deep breathing if you can, and make sure you stay hydrated. Drink some orange juice to raise your blood sugar and lessen the high. A cold shower might also help, along with distractions like funny movies or calming music. CBD—which is effectively an antidote for THC—can also be taken as a tincture for rapid relief capsules take longer to work.
Check here for state-by-state laws on cannabis cultivation in the US. In the UK, for example, police may not even bother investigating unless more than nine plants are suspected. As of October in Canada, for example, when recreational use becomes legal, cultivation will be limited to a maximum of four plants per residence—unless of course you have a license. Joints and blunts are popular for their simplicity, convenience, and rapid onset of effects—and there are plenty of variations to discover. On the other hand, they waste a lot of smoke and may be tricky to roll.
Pipes are even more convenient, but a single hit can sometimes be insufficient for more experienced users. Bongs address this problem but often at the expense of portability, since they tend to be pretty large. They also take some getting used to, so beginners may waste smoke or experience chest pain. Vaporizers are by far the most efficient method, offering a cleaner, healthier feel.
Many vaporizers are also designed for discretion, such as models resembling regular asthma inhalers. On the other hand, they also take longer to kick in and can be far more potent when they do. While cannabis marijuana, pot, etc. In compliance with regulations, hemp also has negligible amounts of THC and is therefore non-psychoactive. Hash is made by separating out the resinous trichomes from the rest of cannabis plant—either by sieve, hand, ice-water, or butane—and compressing them into a block or paste.
Inferior quality hash may also contain adulterants for bulk, such as sand, henna, or plastic. Since hash is a concentrated form of cannabis, it tends to have more THC than weed the whole dried buds. A joint is a hand-rolled cannabis cigarette containing around half a gram of cannabis. A blunt, on the other hand, is made by emptying the tobacco from a cigar and filling the shell with cannabis. Pre-rolled blunt wraps can also be used for the purpose. Detailed instructions can be found here. On average, one gram of cannabis is likely to contain mg THC.
However, this varies widely so it helps to know your strain. More information on calculating doses is available here. Microdoses range between mg THC, but 5 mg is often suggested as a good starting point. Microdosing cannabis may help to relieve anxiety, depression, chronic pain, stress, inflammation, indigestion, and symptoms of ADHD.
For more information, read our guide. Different strains of cannabis have different effects — indica can be more sedative, while sativa can be more energizing.
For more information about the different strains of cannabis, read here. Frequent cannabis use produces tolerance by decreasing the availability of CB1 receptors in the brain. But these should start to replenish after a couple of days of abstinence, returning to normal levels within four weeks.
Cannabis is often taken alongside other drugs. For example, combined with classical psychedelics like LSD or psilocybin, it tends to intensify and prolong the effects. Cannabis can also potentiate dissociatives like ketamine. Combined with alcohol, though, it may lead to nausea and dizziness—especially when the alcohol comes first. Always remember that combining drugs—even with cannabis—can be risky. For more information, click here. Founders of Western civilisation were prehistoric dope dealers. Cannabis: Evolution and Ethnobotany.
The Secret History of Cannabis in Japan. The Asia-Pacific Journal, 12 History of Cannabis as a Medicine. Cannabis and Culture.
Chicago, Illinois: Aldine Publishing Company. History of cannabis as a medicine: a review. Revista Brasileira de Psiquiatria, 28 2. A Collection of Bhang Recipes. Big bhang: It brings out the real you. Cannabis Timeline. Rastafari — Way of Life. The Rastafarians. Boston, MA: Beacon Press. The Chrism in the Gospel of Philip.
Marijuana and the Bible. The Assassins. Reefer Madness: A History of Marijuana. New York, NY: St. Queen Victoria on cannabis, and all the other things you never knew about drugs. Spoonfuls of paradise. A cannabis reader: global issues and local experiences. History of Cannabis in India. The Truth About Indicas and Sativas. Cannabis, a complex plant: different compounds and different effects on individuals. Therapeutic Advances in Psychopharmacology, 2 6 : Cannabinoid pharmacology: the first 66 years.
The Science of Marijuana. The origins of Skunk. Cannabis Prohibition: A British History. The Truth About Marijuana. For research I also: Worked in a medical marijuana shop in Malibu. Smoked pot with Snoop Dogg. Smoked freebase with Rick James. Performed on a rap song with Ice Cube. Frequented Hollywood Boulevard and the Hollywood Station police precinct.
King I eventually met both Rodney and one of the two friends who was with him in the car that fateful night. And of course I spent nearly two decades as a husband and a coach and remain a father to this day of a bi-racial child. I think he would do great with High Tolerance. Boogie Nights is a classic because it caught the zeitgeist of the era, the universality. I think High Tolerance tries to go there too. All artists have inside them a similar creative flame.